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Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells

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doi: 10.1186/gm367

Although direct evidence for autophagy modulation through BRD4 and mTORC1/2 coinhibition is limited, this strategy has shown synergistic tumor cell death in rhabdomyosarcoma by disrupting transcriptional and cytoplasmic signaling simultaneously, 412 indicating future relevance for autophagy therapies