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Color-changing eye drops aren't approved by the FDA, haven't been tested for safety or effectiveness, and could potentially damage people's eyes, the AAO warns

Mosharov E, et al

BMC Ecol

15,16 Unfortunately, these systems have exhibited success with only a small set of peptide therapeutics on account of manufacturing and delivery challenges including low drug loading efficiency that restricts accessible doses and wastes precious drug, poor stability during encapsulation which often requires exposure to organic solvents, and poor control over the duration of drug release

That cardiovascular indication is a clinically and commercially powerful differentiator