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Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor

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JAMA Internal Medicine, 184 (7), 854

The disposition profiles of three of the six major kavalactones (kavain, methysticin and desmethoxyyangonin) and their respective metabolites (p-hydroxykavain, m,p-dihydroxykavain and p-hydroxy-5,6-dehydrokavain) were examined in the perfusate and bile of the isolated perfused rat liver by Fu et al (Ma et al., 2018)