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391 GLP-1 and GLP-1 analogs exert their effects on food intake and body weight through a myriad of neural substrates, encompassing several hypothalamic nuclei (including the arcuate nucleus of the hypothalamus, periventricular hypothalamus, and lateral hypothalamic area), hindbrain nuclei (such as the parabrachial nucleus and medial nucleus tractus solitarius), the ventral subregion of the hippocampus (vHP), and nuclei embedded within the mesolimbic reward circuitry (including the ventral tegmental area, VTA, and nucleus accumbens, NAc)

Even Smoothie Kings 20-ounce Gladiator GLP-1 Vanilla smoothie contains more calories, sodium, and cholesterol than an original glazed doughnut from Krispy Kreme

I was definitely over-consuming alcohol for 15 years, from age 20 to 35

But physiology is foundational