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Clinical and Scientific Updates for Molecular Subsets of Colorectal Cancer

For instance, one drug could interfere with the metabolism of another, leading to increased drug levels and potential toxicity, or decreased levels, leading to reduced efficacy

The serum-induced increase in p53 ubiquitination was blocked by a PI3K inhibitor, suggesting that phosphorylated Akt enhances the ubiquitination-promoting function of MDM2, determining reduction of the p53 protein

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