Research shows that levels can drop by up to 30% by age 40 and up to 50% by age 70
In addition to their roles in bone development and remodeling, osteocytes are also a source of hormonal factors, like FGF23, which modulate mineral homeostasis by acting on distant organs, such as kidney, muscle, parathyroid glands and other tissues (62)
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In the placebo group, there was a loss in lean body mass (-2.62 +/- 1.51 kg) and a negative nitrogen balance (-4.52 +/- 3.51 g/day)
(Kosuru R, Singh B, Lakshmikanthan S, Nishijima Y, Vasquez-Vivar J, Zhang DX, Chrzanowska M.) Front Cell Dev Biol