Any weight-related changes require consistent use for at least 8 to 12 weeks, combined with appropriate diet and exercise, which mirrors the patience required when starting GLP-1 medications and waiting for results to materialize
The NIH Tolerable Upper Intake Level from supplements is 350 mg, but that limit was set based on the laxative effect of cheaper forms
10.1016/S0002-9440(10)64051-5 Am J Pathol
Watch for two issues: grapefruit's acidity can worsen evening reflux in people prone to it, and the sugar can disrupt sleep if eaten within 90 minutes of bed
While the precise pathogenesis remains elusive, current hypotheses implicate abnormal aggregation of -synuclein, mitochondrial dysfunction, calcium dyshomeostasis, oxidative stress, and neuroinflammation (146)