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The pharmacokinetics of vitamin C

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Ulas T, Pirr S, Fehlhaber B, Bickes MS, Loof TG, Vogl T, Mellinger L, Heinemann AS, Burgmann J, Schoning J, Schreek S, Pfeifer S, Reuner F, Vollger L, Stanulla M, von Kockritz-Blickwede M, Glander S, Barczyk-Kahlert K, von Kaisenberg CS, Friesenhagen J, Fischer-Riepe L, Zenker S, Schultze JL, Roth J, Viemann D (2017) S100-alarmin-induced innate immune programming protects newborn infants from sepsis

It requires weight-based dosing and IV or SubQ administration under clinical supervision

The earliest sign of response is reduced shedding at 4 to 8 weeks, but visible new growth requires 8 to 16 weeks and meaningful density change takes 4 to 6 months