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Gastrointestinal adverse effects are the most frequently reported and include: Nausea (very common, affecting more than 1 in 10 people according to the SmPC) Vomiting Diarrhoea Constipation Abdominal pain or discomfort These symptoms are usually mild to moderate, transient, and tend to improve over time as the body adjusts to the medication

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revenue generated by each of these top-selling products in their first five full years on the market