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Synthesis of diiodo(p-cymene)ruthenium(II) dimer (compound 4) The diiodo(p-cymene)ruthenium(II) dimer was synthetized using a similar procedure as previously reported 12

KPV: As a fragment of alpha-MSH, an endogenous hormone, KPV inherits a theoretically favorable safety profile

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The 500 mcg per-capsule dose mirrors the per-day intake used in the bulk of rodent oral studies, and the gastric origin of the parent molecule provides a biological rationale for stability through the GI tract a feature documented across multiple oral-administration preclinical models