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However, in support of a causal relationship, lowering of HR by ivabradine, a selective inhibitor of the sinus node I(f) channel, devoid of any activity on blood pressure, cardiac contractility, atrioventricular conduction or ventricular repolarization, decreased the risk of cardiovascular death or hospitalization due to heart failure (HF) in subjects with HF, which is a debilitating condition highly sensitive to changes in HR [40]