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Therefore, raising cellular NAD + through vitamin B3 family precursors or via drug-based interventions has become a broadly used strategy to restore mitochondrial and organismal homeostasis, with NAD + precursors becoming a popular supplementation approach

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While these findings highlight SIRT1s protective role in ferroptosis regulation via the p53/p21 axis, further research is needed to elucidate its context-specific effects across different disease models