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296 , E1354E1362 (2009)

For instance: If you take your B12 via the sublingual route (under your tongue) or via a shot (injection) you will probably need less than if you take your B12 in a capsule

The main mechanism of drug induced liver injury is due to the toxicity of the drug itself and the immune reaction, most of the drugs are transformed by hepatocytes, and normal medication will not cause liver injury, but after overdose, a large number of drugs are transformed into water-soluble metabolites by hepatocytes, and the generation of these substances will greatly consume the glutathione in the hepatocytes, resulting in hepatocellular necrosis, and the exogenous glutathione can reduce the toxicity of the drug and the immune reaction, which will cause the liver cell necrosis

Ethics declarations Competing Interests JMP and SC acted as advisors for Abbott

In addition, overall mean body weight of all participants was 91.5 kg and, as such, it is uncertain whether our findings are applicable to individuals with type 2 diabetes who are not overweight or obese