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Potential liver issues: Takings high doses of creatine in the long term have raised concerns about liver function, though no strong evidence links it to liver damage in people who have no health conditions

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However, patients should contact their healthcare provider if they experience severe or persistent side effects

Physiologically based pharmacokinetic models are effective support for pediatric drug development

The available anthropometric measures, which were limited to BMI and waist circumference, were no longer associated with time to weight plateau in the modelled analyses