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It can also be combined with other diabetes drugs like metformin

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Anal Biochem 72(12):248254 Brazier-Hicks M, Knight KM, Sellars JD, Steel PG, Edwards R (2018) Testing a chemical series inspired by plant stress oxylipin signalling agents for herbicide safening activity

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It was demonstrated in one study that spermidine, similarly to curcumin and quercetin, exerts properties of epigenetic regulator and induces autophagy in vitro by inhibiting histone acetyltransferase p300 (EP300), which suppresses function of several autophagy proteins [133]