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Side effects, when they occur, are commonly gastrointestinal and often improve with time and supportive habits

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The final histopathologic diagnosis was vulvar melanosis for all biopsied lesions

In addition, a study comparing the effects of acupuncture and metformin in obese/overweight women and thin women with IR and PCOS found that acupuncture and metformin showed similar effects in thin women with IR and PCOS, but in those of obese/overweight women, acupuncture was less effective in increasing insulin sensitivity compared to metformin [144]

Consistency is key, especially for topical applications or injection cycles