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DS individuals have decreased efficiency in producing ATP and reduced respiratory capacity

Curr Pharm Design 24(40):47114725 Cai H, Cong WN, Ji S, Rothman S, Maudsley S, Martin B (2012) Metabolic dysfunction in Alzheimers disease and related neurodegenerative disorders

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J Biol Chem 285(1):723730 Vilsbll T, Holst JJ (2004) Incretins, insulin secretion and type 2 diabetes mellitus