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In contrast, CR-fed females not only had reduced plaques, but had reduced glial activation relative to both CR and DL-fed mice, with substantially lower pro-inflammatory gene expression, suggesting that while caloric reduction alone may attenuate plaque pathology, the reduction in plaque deposition observed in the DL-fed mice may not be mediated by glial cells

Similarly, sophocarpine had LC 50 values of 50.1 mg/L for minor workers and 85.9 mg/L for major workers (Tian and Zhang, 2023)

Some research into the likely source of the fraud has been conducted