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Despite no evidence of this same effect in humans, GLP-1s aren't recommended for people with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome 2 (MEN 2)
The cardiovascular benefits of this pairing extend beyond weight lossboth medications independently reduce heart disease risk, and together they lower the incidence of major adverse cardiovascular events (MACE) in high-risk populations
PMID: 18 van StaaTLeufkensHAbenhaimLBegaudBZhangBCooperC
But they do not provide meal plans, dietary guidance, or behavioral coaching as part of their service
Chronic stress reduces the appetite-suppressing effectiveness of GLP-1s, and perimenopausal estrogen decline dysregulates the HPA axis that cortisol and GLP-1 mechanisms share, raising baseline cortisol
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