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Glutathione may interact with certain medications metabolized via glutathione conjugation, and excessive antioxidant activity can theoretically blunt beneficial inflammatory signaling during metabolic adaptation

Diabetes 68(Supplement_1) Cui Y et al (2021) Melatonin prevents diabetes-associated cognitive dysfunction from microgliamediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway

Tirzepatide: It activates both GLP-1 and Glucose-dependent Insulinotropic Polypeptide (GIP) receptors

Meier JJ, Rosenstock J, Hincelin-Mery A et al (2015) Contrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: a randomized, open-label trial

The net cost of the programs varies, and select PBMs are adjusting rebates and assessing integration and management fees when vendor programs are implemented