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Mechanistically, p53 decreases the monoubiquitination rate of histone H2B on lysine 120 (H2Bub1) in the SLC7A11 gene regulatory region by facilitating the nuclear translocation of the deubiquitinase USP7, leading to the inactivation of SLC7A11 expression in erastin-treated cells [122]

Its also remarkably stable unlike many peptides that degrade in acidic conditions, BPC-157 resists low-pH environments, an unusual structural property in its class

That means for the same current, the voltage drop is smaller