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Contraindications include: Personal or family history of medullary thyroid carcinoma Multiple endocrine neoplasia syndrome type 2 (MEN2) History of severe pancreatitis (use with caution) Why gradual dose titration matters: Gradual dose escalation is essential to minimize side effects
Broad safety impact of high-dose ascorbic acid and induction chemotherapy for high-risk pancreatic cancer
Any suspicion of pancreatitis warrants immediate medical evaluation and discontinuation of tirzepatide pending investigation
Are there safer weight loss alternatives to tirzepatide for Crohn's patients
"Of course, there is a theoretical performance advantage in sports that have weight classes or sports like cycling and long distance running where weight is a factor, but because the GLP-1s suppress appetite and cause muscle loss as well as fat loss, they aren't necessarily going to improve performance." However, Eichner also points out that not much is known about potential performance-enhancing effects of GLP-1s, and more research needs to be done
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