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In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

Nevertheless, certain questions and limitations remain to be addressed

Mishra M, Afzal S, Yadav R, Singh NK, Zarbakhsh S

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Coot: model-building tools for molecular graphics