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(1) Not recommended for the treatment of chronic kidney disease in patients with polycystic kidney disease or patients requiring or with a recent history of immunosuppressive therapy for the treatment of kidney disease

So how significant is this concern in 2026, and how should clinicians respond

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[DOI] [PubMed] [Google Scholar] Iwase S., Kawaguchi T., Yotsumoto D., Doi T., Miyara K., Odagiri H., Kitamura K., Ariyoshi K., Miyaji T., Ishiki H., Inoue K., Tsutsumi C., Sagara Y., Yamaguchi T

Deubiquitinating enzymes (DUBs): DoUBle-edged swords in CNS autoimmunity