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GLP-1 injections: Evidence and efficacy In contrast to patches, GLP-1 injections have extensive clinical evidence supporting their effectiveness: Clinical trial results Wegovy (semaglutide) : The STEP clinical trials involved thousands of participants and showed average weight loss of 15% after 68 weeks

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The STEP program (including STEP 1 and related trials) demonstrated clinically meaningful weight loss across populations and established semaglutide as a new standard for many patients with obesity

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