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Users are advised to supplement with TUDCA or NAC to reduce hepatotoxicity during RAD-140 supplementation, increase water intake to prevent dehydration, and add the following spices to stimulate appetite: Black pepper Mint Ginger Cinnamon Relevant Research Design, synthesis, and preclinical characterization of the SARM RAD-140 Human in vivo metabolism and elimination behavior of micro-dosed SARM RAD-140 for doping control purposes Ostarine During a study published in the Journal of Cachexia, Sarcopenia and Muscle , Ostarine was administered to 120 men over the age of 60 for 12 weeks