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The biologic effects of IGFs signaling on cancer Once activated by the ligands, IGF-IR and InsR may initiate diverse signaling pathways to regulate cell proliferation, differentiation, survival, metabolism, migration, and stemness (Fig

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By improving cellular uptake of compounds such as glutathione and phosphatidylcholine, these formulations allow for lower dosing with more consistent tissue exposure, reducing metabolic strain during toxin mobilization