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Growth hormone plays a central role in muscle growth, fat metabolism, recovery, and overall body composition

Pharmacokinetics: metabolized through the hepatic cytochrome P450 system Side Effects / FDA Warning: The FDA issued a black box warning to indicating an increased risk of heart failure with both pioglitazone & rosiglitazone Long term therapy is associated with a small increase in HDL & LDL & a decrease in Triglycerides The triglyceride lowering effect of pioglitazone is greater than that of rosiglitazone, presumably due to its stimulatory effects on PPAR- (which may be due to decreased osteoblast formation)

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doi: 10.1038/s41575-022-00631-9 13 CentanniM.BenvengaS.SachmechiI