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The patient has established cardiovascular disease with a documented history of at least one of the following: A) Previous myocardial infarction (MI) B) Previous stroke C) Symptomatic peripheral arterial disease (PAD), evidenced by one of the following: Intermittent claudication with an ankle-brachial index (ABI) less than 0.85 at rest Peripheral arterial revascularization procedure Amputation due to atherosclerotic disease D) Prior revascularization, such as coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), or angioplasty, and

doi: 10.1536/ihj.19-372 107 WangYChenBHuangCKGuoAWuJZhangXet al

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Based on the role of TMAO in the progression of HF, regulating TMAO levels is a new and attractive therapeutic target for HF treatment (111)

Finally, regular exercise, including cardio and strength training, plays a key role in weight management by encouraging fat-burning and building muscle mass