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How well you tolerate the medication
doi:10.1161/HYP.0000000000000249 5
After being ingested, these phenolic compounds undergo biotransformation and are broken down in the colon by microbial enzymes yielding smaller, bioavailable molecules that can then be absorbed by the colon into the bloodstream and transported to tissues and organs (Trebatick and urakov, 2015)
Those with poor circulation in the lower extremities (peripheral vascular disease) may experience altered absorption rates
As you already imagined, there are different subtle ways to suppress the adrenaline boost
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