To exclude the possibility that high plasma insulin or low glucose levels could contribute to observed increases in serotonin in the postprandial state, we analyzed serotonin levels in response to hyperinsulinemic-hypoglycemic clamps in PBH, Asx, and Ow/Ob participants (Supplemental Figure 16A)
Phase 2 Obesity Trial Jastreboff et al., New England Journal of Medicine (2023) Jastreboff and colleagues conducted a phase 2, double-blind, randomized, placebo-controlled trial of retatrutide in adults with obesity
Billings presented the latest data at EASD 2024, which showed that IcoSema led to similar A1C reductions and greater weight loss with less severe hypoglycemic episodes compared to daily basal-bolus insulin
The greater impact on morbidity and mortality of diabetes in patients who develop the condition at a younger age compared to those who develop it later [77]
Smaller barrels read more clearly for low-volume doses