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For those primarily concerned with scale weight and metabolic health markers, monotherapy may suffice

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According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, weight loss medications should be offered as chronic treatment along with lifestyle modifications to patients with obesity when the potential benefits outweigh the risks

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Therefore, clonidine therapy must always be tapered gradually over a minimum of 2 to 4 days (or weeks for higher doses), and any concurrent beta-blockers must be discontinued several days prior to beginning the taper (JAVADIN, 2025