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How it works: MOTS-C is a naturally occurring mitochondrial peptide discovered at USC in 2015
Evers, A
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However, metoclopramide speeds stomach emptying and may reduce GLP-1 effectiveness, so it's best used short-term
While some hypotheses suggest central nervous system effects of GLP-1 receptor agonists might play a role, these mechanisms remain speculative and require further research to establish definitive links to headache symptoms
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