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however, this timeframe was selected to maintain uniform data availability in TriNetX and to reduce time-varying confounders

This has important implications for muscle biology: GH-dependent skeletal muscle anabolism is partially dependent on pulsatile GH signalling for GHR internalisation-recycling kinetics, and sustained GH elevations (as produced by CJC-1295/DAC) generate a different GHR occupancy profile than pulsatile endogenous GH