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3 Renal cellular uptake and biotransformation of cisplatin (CP) The kidney is the main route of CP excretion, since it has been demonstrated that the concentration of CP in the kidneys is five-fold greater than that in the blood, and therefore such accumulation of the drug within the kidney cells contributes to its nephrotoxicity (Ozkok and Edelstein, 2014

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A higher Pgp activity during the night period also may have contributed to the differences between morning and night Tac administrations observed