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Tegsedi (Inotersen): an antisense oligonucleotide approved for the treatment of adult patients with hereditary transthyretin amyloidosis

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To summarize, it has been reported by different research groups in different experimental models that MCFAs exert neuroprotective effects without measurable elevation of HB levels in the hippocampus (55, 74) or the whole brain (59, 114), while the MCFA concentrations (when they were measured) were elevated in both plasma and the brain