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Clinical studies show that injectable semaglutide produces greater weight loss in most patients compared to oral formulations at equivalent doses

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The clinical approach remains sound regardless of whether the specific mechanism is correct

Enhancing the functional status of patients with HFpEF is crucial, highlighting the need for innovative treatments, particularly for obesity-related HFpEF [29]

However, large-scale cardiovascular outcome trials for semaglutide have not found a statistically significant increase in the incidence of these conditions in humans