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Br J Clin Pharmacol 32:768770 Bannwarth B, Netter P, Lapicque F, Gillet P, Pere P, Boccard E et al (1992) Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol

IL-1 receptor antagonist plus pentoxifylline and zinc for severe alcohol-associated hepatitis

Overdosing by even 2030% can shift your subject into a different dose-response range and compromise study reproducibility, particularly in dose-escalation protocols where each dosing tier is precisely defined

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On the dose-response curve of the effect of intraperitoneal BPC-157 on the flinching response in the formalin test, BPC-157 led to significant suppression of the flinches in a dose-dependent manner in phase 1 but showed little effect in phase 2 (Fig