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When speaking with your doctor, it may be helpful to: Share your weight management history , including previous treatments, lifestyle interventions, and any underlying conditions such as type 2 diabetes, hypertension, or sleep apnoea Ask about currently approved options , such as orlistat (available on the NHS

GIP stands for glucose-dependent insulinotropic polypeptide, another hormone released in the gut when we eat

The once-daily Wegovy pill demonstrated up to 17% average weight loss when used along with a reduced calorie diet and exercise

Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist for Obesity Treatment

But in the Retatrutide Phase 2 Obesity trial, Low Wang said that 100% of study volunteers who received 8 milligrams or more of the medication rather than the placebo lost at least 5% of their body weight