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Obesity contributes to the pathology of many nervous system disorders, including stroke [9], and importantly increases the disability burden among stroke survivors with type 2 diabetes [10]

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Conversely to the hormone leptin, ghrelin stimulates neuropeptide Y neurons and inhibits hypothalamic POMC neurons [89]

Metabolomics studies in recent years have revealed that the alteration in the spectrum of carnitine and its acyl derivatives can be captured at the molecular stage of DKD occurrence, showing a significant advantage over traditional clinical indicators [20, 48, 142, 143]