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B12 injections provide significant benefits including increased energy levels, improved mood, cognitive function, and alleviation of deficiency symptoms, especially for at-risk groups like older adults and those with digestive disorders

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Experiments have shown that the specific inhibitor of PIEZO1 can significantly reduce iron overload, inhibit mitochondrial oxidative stress, and block the characteristic changes of ferroptosis induced by mechanical stress (Liu et al., 2025)

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Table 2 Randomized controlled trials (RCTs) of Vitamin Dgeneral population and CKD cohorts