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TB-500 (synthetic TB4) has been clinically tested for its wound healing potential, with the following two studies worth noting: In a randomized, double-blind, placebo-controlled study with dose escalation, patients suffering from venous stasis ulcers were administered synthetic TB4 locally over a period of 84 days

Instead, existing cartilage cells (#chondrocytes) were reprogrammed toward a more youthful gene-expression profile, decreasing #inflammatory and cartilage-degrading cell subtypes and increasing cells that support healthy articular cartilage and its extracellular matrix

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In burn and wound models, it sped up closure and improved granulation tissue