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Absolute contraindications to phentermine, regardless of GLP-1 status: Uncontrolled hypertension History of coronary artery disease or heart failure Uncontrolled hyperthyroidism Glaucoma History of substance use disorder (phentermine is Schedule IV) Use within 14 days of MAO inhibitors Pregnancy or planning pregnancy Age over 65 (relative contraindication) The GLP-1 alone may still be appropriate in many of these scenarios

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10.3389/fphar.2021.739615 21 ChenX.WeiW.LiY.HuangJ.CiX

Wait for about 24 hours after the first dose before using another

This ensures that healthcare providers have real-time access to patient data, enabling more informed and proactive decision-making