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For most patients, gastrointestinal-related side effects of retatrutide are transient and diminish after a few weeks as the body adapts

15% average body weight loss after 12 months (2.4 mg dose/Wegovy)

Some studies document pain, swelling, redness, bruising, and itching resulting from a variety of factors: Histamine release, immune response to the peptide, needle trauma, and/or irritation from preservatives and buffers

However, it's essential to consider the potential benefits and risks, as well as the need for lifestyle adjustments and regular monitoring by a healthcare provider

In some cases, vitiligo may gradually spread, but progression differs for every patient