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For years, researchers hypothesized that acute viral infections, like the initial SARS-CoV-2 infection that triggers Long COVID, simply depleted the body's glutathione stores, leaving the patient defenseless against inflammation

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Serious adverse reactions seen in pediatric patients using topiramate include acute angle glaucoma, oligohidrosis and hyperthermia, metabolic acidosis, cognitive and neuropsychiatric reactions, hyperammonemia and encephalopathy, and kidney stones

It will depend on the ability to connect multiple sources of evidence, including: Clinical trial data Real-world clinical data Patient-reported outcomes Biomarker and genomic information Healthcare utilization data Digital health technologies The goal is not to replace randomized clinical trials but to complement them, creating a more complete picture of how therapies perform in real-world healthcare settings

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