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Cook S, Togni M, Schaub MC, Wenaweser P, Hess OM

These minor metabolites could also be detected after APAP exposure (but at lower levels), and in vivo in the men and PWs, but at much lower levels than the thiomethyl metabolites (AUCs for SAMP in the men and PW correspond to less than 4% of all combined AUCs in vivo, see tables S1 and S2)

In this cancer, the failure of imatinib mainly depends on mutations of the tyrosine-protein kinase KIT and the platelet-derived growth factor receptor (PDGFR)