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Various physiological roles of TAU have been suggested, including calcium modulation, membrane stabilization, intracellular osmotic regulation and the regulation of protein phosphorylation 7, 8, 9, 10, 11, 12

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A previous study showed that NLR family pyrin domain containing 3 (NLRP1/3) inflammasome levels are elevated in both parenchymal and nonparenchymal cell types in an HFD-induced mouse model of NASH [39]