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Mechanistically, IF reduces systemic inflammation, alters the distribution of adipose tissue, and increases thermogenesis, which in turn supports insulin signaling pathways and enhances metabolic flexibility [49]

Neurons and microglia can detect and sense cytosolic mtDNA, driving neuroinflammatory responses characterized by cytokine production, inflammasome activation, and recruitment of peripheral immune cells [12]

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Different components of the Trx system, including TrxR1, Trx, and Prx are acetylated at multiple lysine residues in mammalian cells (Choudhary et al., 2009