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R NQO1 Substrates NQO1 processes a wide range of substrates: Benzoquinones (from benzene metabolism, industrial exposure) Catechol estrogen quinones (from estrogen metabolism by CYP1A1/CYP1B1) CoQ10 (ubiquinone to ubiquinol reduction) Menadione (vitamin K3) Mitomycin C and other quinone-containing chemotherapy drugs Naphthoquinones Polycyclic aromatic hydrocarbon (PAH) quinones (from cigarette smoke, grilled food, air pollution) NQO1 and NRF2 NQO1 gene expression is controlled by the antioxidant response element (ARE) in its promoter region, which is activated by the transcription factor NRF2

Gastinel LN, Simister NE, Bjorkman PJ

Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

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