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This naturally occurring molecule (S-adenosylmethioine) delivers sulfur to the cartilage, which helps build strong joints

According to the Centers for Disease Control and Prevention (CDC), prolonged use of opioid-containing medications like Vicodin (hydrocodone/acetaminophen) and Percocet (oxycodone/acetaminophen) results in physical dependency, withdrawal symptoms, and substance use disorders

Moreover, chronic pain itself has been associated with impairments in attention, memory, and other cognitive domains, as documented in clinical literature on pain-related cognitive dysfunction, which may confound the interpretation of neurobehavioral outcomes in these patient populations (Patel et al., 2025)

doi: 10.1016/j.pnpbp.2013.02.015